The Virtual Hospital

ElectricPE: The Diagnosis of Pulmonary Embolism: Case Study 29

Non-Small Cell Carcinoma

Jeffrey R. Galvin, M.D. and James J. Choi, B.S.
Peer Review Status: Internally Reviewed


This case is a 60 year old male with non-small cell carcinoma of the lung metastatic to the right kidney and both adrenals. He developed sudden onset of dyspnea, anxiety, tachypnea and tachycardia. His blood gases at the time of presentation were: PH 7. 51, PCO2 30 and PO2 52 on room air.

The portable chest radiograph shows a density in the posterior basilar segment of the left lower lobe.

The perfusion scan demonstrated 2 perfusion defects in the left lung. #1 is a subsegmental defect in the superior segment of the left lower lobe and #2 is a larger non-segmental defect in the left lower lobe. A ventilation scan could not be completed due to the patients condition. The interpretation at the time was "Findings most likely represent parenchymal or airway disease although superimposed PE can't be excluded".

The initial venous injection into the femoral vein revealed clot extending from the right renal vein into the inferior vena cava. In addition, there were filling defects in vessels leading to the right lower lobe. The left lung was normal.

Case Assessment
This was a 60 year old male who was predisposed to deep venous thrombosis because of prolonged bed rest and an underlying malignancy. He presentedwith dyspnea, anxiety, tachypnea, tachycardia, and respiratory alkalosis.

1. The angiogram demonstrated multiple clots in the right lung in the same area where the perfusion scan is essentially normal.

Although the perfusion scan is generally recognized as a sensitive test for pulmonary emboli, non-occlusive clots can be missed.

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