The Virtual Hospital

ElectricPE: The Diagnosis of Pulmonary Embolism: Case Study 21

Oral Contraceptives

Jeffrey R. Galvin, M.D. and James J. Choi, B.S.
Peer Review Status: Internally Reviewed


This case was 20 year old female smoker who presented to her local hospital with a 2 day history of back pain and shortness of breath. Her only medicationwas oral contraceptives. A chest x-ray taken at that hospital revealed rightlower lobe atelectasis and a right sided pleural effusion. Aventilation/perfusion scan done at that time was read as low probability for pulmonary embolus. She underwent a renal work up to help explain her back pain which was unrevealing.

She was transferred to this hospital one month after the inception of her symptoms with a differential diagnosis which included : costochondritis, lumbar muscle strain and urinary tract infection.

The chest radiograph done at this hospital revealed a right pleural effusion shown best on the lateral view.

The perfusion scan revealed a subsegmental defect in the superior basal segment on the right. There were multiple smaller defects along the lateral margin of the left lung. The ventilation scan was normal. The final reading was intermediate probability of pulmonary embolus.

The pulmonary angiogram demonstrated an oblong defect which extended into the proximal portions of both the middle lobe and lower lobe arteries, consistent with the diagnosis of acute pulmonary embolus.

Repeat chest x-ray done 2 weeks later showed clearing of the pleural effusion on the lateral view. A repeat perfusion scan done at the same time shows interval resolution of the perfusion defects after treatment with heparin.

Case Assessment
This is a case of a 20 year old female whose only apparent risk factor was oralcontraceptive and presented with:

1. This patientÕs initial V/Q scan at the outside hospital (not available) was read as low probability and the diagnosis of pulmonary embolus was therefore, dropped from the differential diagnosis list. It should be remembered the Òlow probabilityÓ category is less reproducible than either the normal or high probability categories and is therefore less useful to plan therapy. (RADIMAGE)

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